BCR-ABL1 Genetic Test Test
This test looks for an abnormal gene called BCR-ABL1 in your blood or bone marrow. It helps diagnose certain blood cancers and check if treatment is working.
What this test measures
A BCR-ABL1 genetic test uses a sample of blood or bone marrow to look for an abnormal gene called BCR-ABL1. This gene is formed when pieces of chromosomes 9 and 22 break off and trade places, creating a fusion gene that can cause certain types of blood cancer.
What your results mean
Reference ranges vary by laboratory and by your age and sex. MedlinePlus does not publish a single normal range for this test — always read your result against the range printed on your own lab report and discuss it with your provider.
Higher-than-normal results
If the amount of BCR-ABL1 in your sample increases, it may mean your treatment is not working. An increase after successful treatment may mean your cancer has come back.
Lower-than-normal results
If the amount of BCR-ABL1 in your sample decreases, it means your treatment is working to some degree.
Frequently asked questions
What is the BCR-ABL1 gene?
It is an abnormal gene formed when pieces of chromosomes 9 and 22 break off and trade places, fusing part of the ABL1 gene with part of the BCR gene.
What cancers are linked to the BCR-ABL1 gene?
It is found in most people with chronic myeloid leukemia (CML) and some with acute lymphoblastic leukemia (ALL).
Is the BCR-ABL1 gene inherited?
No, it is an acquired genetic change that happens after birth and cannot be passed to your children.
How is the test used during treatment?
It is used to see if cancer treatment is working by comparing BCR-ABL1 levels over time.
What does a decrease in BCR-ABL1 mean?
A decrease means your treatment is working to some degree.
Related lab tests
Sources
- MedlinePlus: BCR-ABL1 Genetic Test — NIH MedlinePlus
Last updated . Information is aggregated from official public sources and is not a substitute for professional medical care.